In a model of NSCLC that commonly exhibits DNA hypermethylation, the upregulation of PD-L1 transcripts and protein was observed upon treatment with 5-azacytidine [77] and similarly an induction of PD-L1, PD-1, PD-L2, and CTLA-4 expression was noticed in a cohort of leukemia treated with decitabine [73]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.