CALR and neoplasm: In a model of colorectal cancer, cotreatment of cells with inhibitors of both DNMT and HDAC combined with IFN type I triggered several hallmarks of immunogenic cell death (calreticulin exposure and HMGB1 release) enhancing the recruitment into tumor bed of dendritic cells and their maturation into antigen-presenting cells thus facilitating tumor cell lysis by CTL [101].