It is likely that they subsequently orchestrate the actin-binding proteins: regulators of assembly and disassembly (CAPZ, CAPN2, CFL1, and PFN1), nucleators (ARPC1A, ARPC2), crosslinkers (ACTN1, FLNA), and actin-membrane linkers (MYH10, MYH14) to form cortical actin network and the stress fibers in advanced prostate cancer cells [73,74]. Here, PFN1 is linked to Familial prostate cancer.