Then, a few years later, it was shown that autosomic recessive mutations of the RELN gene were linked to a form of lissencephaly with cerebellar hypoplasia (LCH) [9], with associated findings suggested that RELN was linked to some neuropsychiatric conditions [10], and RELN was demonstrated to be reduced in the cerebellum of autistic patients after Western blotting and immunodetection [11]. Here, RELN is linked to lissencephaly spectrum disorders.