Very recent observations demonstrated that heterozygous RELN mutations give rise to a classic ADLTE syndrome, clinically identical to that associated with mutations of LGI1. Seven different heterozygous missense mutations in RELN were, in fact, described in some unrelated families of Italian ancestry with familial temporal lobe epilepsy-7 (ETL7–OMIM #616436) [106]. Here, RELN is linked to familial temporal lobe epilepsy 7.