A study carried out on mice whose mothers were stressed during pregnancy showed that the downregulation of Reln and GAD67 was associated with a hypermethylation of their promoters [232], this being one the mechanisms in support for the contribution of an altered epigenetic control in the down-regulation of RELN expression in schizophrenia, see [233] for review. This evidence concerns the gene GAD1 and schizophrenia.