More et al. studied it in greater detail—in a subset of patients with multilocular and multilocular-solid tumors (based on ultrasound), the best cut-off values for CEA alone and the CA-125/CEA ratio for discrimination between ovarian primary (including benign and malignant) and metastatic tumors were 2.3 and 11.9, respectively [11]. Here, MUC16 is linked to metastatic neoplasm.