We were able to quantify SRPX2 in all eight tumor samples (90–860 amol/3 μg; median 470 ± 260 amol) but in none of the six healthy control tissues, indicating a clear upregulation of the protein in CRC, in agreement with previous reports that SRPX2 plays a role in the progression of CRC [47]. Here, SRPX2 is linked to neoplasm.