Gremlin-1 has been associated with improved survival in locally advanced Stage II and III CRC [44], and could not be detected in the WT tumor proteome but was highly expressed in the G12V tumor (GREM1↑G12V) and showed an 11.1-fold higher mRNA level in the G12V tumor, in accordance with the proteome data. This evidence concerns the gene GREM1 and neoplasm.