In summary, dense DNA methylation of ACE, ACE2, SCNN1B, IFN-γ, and CKG correlated with essential HTN, as well as DNA hypo-methylation of ACE2, IFN-γ, TLR2, SCNN1A/1B, GCK, ADD1, and AGTR1 in HTN. This evidence concerns the gene ACE2 and hypertensive disorder.