To investigate the consequences of miRNA disruption in liver physiology, Dicer1 conditional knockout mice were established and showed initial preservation of liver function, followed by the development of progressive liver dysfunctions leading to prominent steatosis, lipid, and glucose metabolism impairment, increased hepatocyte proliferation, and, finally, onset of HCC [30,31]. The gene discussed is DICER1; the disease is hepatocellular carcinoma.