As an example, we reported the dual role for oncomiR-221 in cell proliferation and drug sensitization based on p53 status, as well as the simultaneous targeting of PTEN tumor-suppressor gene and AKT3 oncogene, both belonging to the AKT/mTOR pathway, by miR-519d, which is strongly upregulated in 50% of HCCs [64,65]. This evidence concerns the gene PTEN and neoplasm.