ATG5 and hepatocellular carcinoma: An intriguing mechanism of miRNA degradation was proposed for miR-224 whose expression negatively correlated with autophagy in HBV-related HCCs, as demonstrated by the tissue array of autophagy-associated markers (autophagy related 5 ‘Atg5’, Beclin1, and p62) and ISH for miRNA detection in a cohort of 93 HCC patients.