EGR1 and cancer: Moreover, early growth response 1 ‘Egr1’, activating transcription factor 3 ‘Atf3’ and Kruppel-like factor 4 ‘Klf4’ resulted as the main regulatory factors in HBX mice controlling cancer-associated signaling pathways, such as PI3K/AKT, MAPK, Ras, and p53, which role in hepatocarcinogenesis is well established [59].