miR-494-mediated mTOR pathway activation was responsible for decreased sorafenib sensitization in HCC preclinical models; indeed, rapamycin co-administration triggered apoptotic cell death in miR-494 overexpressing HCC cells, as evidenced by Poly adenosine diphosphate [ADP-ribose] polymerase 1 (PARP-1) and caspase-3 specific cleavage. Here, PARP1 is linked to hepatocellular carcinoma.