Interestingly, MYC oncogene was recently associated with a gene regulatory network formed by lin-28 homolog B (LIN28B), CTNNB1, SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4), Let-7b, SRY-Box Transcription Factor 9 (SOX9), and TP53 that correlated with increased proliferation, dedifferentiation and c-Met pathway activation more likely contributing to the transcriptional signature typical of the HCC “proliferation” subclass [61]. The gene discussed is TP53; the disease is hepatocellular carcinoma.