Others and our group reported the upregulation of miR-494, a member of the Dlk1-Dio3 miRNA cluster, in 25–30% of HCCs with stemness features and demonstrated its involvement in tumor progression and sorafenib resistance through the direct targeting of mutated in colorectal cancer (MCC) and the phosphatase and tensin homolog (PTEN) tumor suppressor gene [15,16]. The gene discussed is PTEN; the disease is colorectal cancer.