As shown in Table 4, IBP and T20 were unable to inhibit any T20-resistant strains at concentrations as high as 1,000 nM and 500 nM, respectively, while IBP-CP24 was highly effective in inhibiting infection by T20-resistant HIV-1 strains with an average IC50 of 21.9 nM, about 1.5-fold of that of CP24. The gene discussed is CYP24A1; the disease is infection.