ITIH4 and HIV-1 infection: Interestingly, combinational use of IBP-CP24 with a broad HIV neutralizing antibody, such as N6, showed synergistic anti-HIV-1 effect, suggesting that IBP-CP24 can be used together with N6 to treat HIV-1 infection because N6, as a biomissile carrying IBP-CP24, binds gp120 to make the first strike, and releases IBP-CP24 that binds gp41 to make the second strike to HIV-1.