These results show that MT-1303 and the anti-mTNF-α mAb inhibit the development of colitis in SCID mice induced by adoptive transfer of CD4+CD45RBhigh T cells from BALB/c mice, and that the inhibitory efficacy of MT-1303 is comparable to that of the anti-mTNF-α mAb. Here, CD4 is linked to colitis.