In fact, studies have reported that S1P1 receptor modulators effectively ameliorate the severity of symptoms in dextran sulfate sodium (DSS)-induced colitis, 2,4,6-trinitrobenzenesulphonic acid (TNBS)-induced colitis, adoptive CD4+CD45RBhigh T cell transfer colitis and interleukin (IL)-10 knockout mice, murine models of experimental colitis [9–11]. This evidence concerns the gene CD4 and colitis.