GPT and hepatitis B virus infection: In the fatal group, the AST and ALT values increased within 8 days of DF onset when compared with those of survivors after controlling of other comorbidities, including viral hepatitis B or C, hematological disorders, hypertensive disease, acute hepatitis, and liver failure (β = 2,812.72 for AST and β = 560.39 for ALT, both p values <0.001) (S1 Table).