CACNA1C and Timothy syndrome: To establish a model for investigating how the Timothy syndrome mutations affect neurodevelopment, we searched for an equivalent mutation in egl-19, the C. elegans orthologue of CACNA1C. We found that the egl-19(n2368) mutation (hereafter referred to as egl-19(gof)) encodes a G365R variant of EGL-19 that is equivalent to the G402R Timothy syndrome variant in human CACNA1C (Fig 1A).