During fibrotic liver diseases, diverse hepatic immune cells, especially macrophages, are dynamically recruited to the injury site in a manner mainly determined by the cytokines and chemokines (C-C motif chemokine ligand 2 [CCL2], C-C motif chemokine ligand 5 [CCL5], C-X-C motif chemokine ligand 10 [CXCL10], etc.)secreted by hepatocytes, HSCs, and endothelial cells [2]. This evidence concerns the gene CCL2 and liver disorder.