TIMP2 and Hepatic fibrosis: As liver fibrosis is accompanied by dynamic ECM remodeling [1], we further found that the transcription of matrix metalloproteinases (MMPs) and MMP inhibitors (tissue inhibitors of metalloproteinases [TIMPs]), including Mmp9, Mmp13, Timp1, and Timp2, were higher in med23Δli mouse livers than in control mouse livers (Fig 1E).