Similar to the CCl4-induced fibrosis model, Med23 silencing also resulted in increasing mRNAs related to liver fibrosis, including Col1a1, Col3a1, Tgfβ1, Pdgfβ, Tgfβr1, Pdgfrβ, and Timp1 (S1A Fig). The gene discussed is COL3A1; the disease is Hepatic fibrosis.