In agreement with the increased exacerbation of liver fibrosis, the mRNA levels of profibrogenic factors such as transforming growth factor beta 1 (Tgfβ1) and platelet derived growth factor beta (Pdgfβ) and their receptors were significantly higher in med23Δli mouse livers than in med23f/f mouse livers (Fig 1F). This evidence concerns the gene TGFB1 and Hepatic fibrosis.