IL36G and Skin rash: Interestingly, the simultaneous binding of these 2 transcription factors to the IL-36γ promoter results not only in an additive but also a synergistic effect on IL-36γ gene transcription, which is of relevance for the characteristic localization of the EGFRi-induced rash to sebum-rich regions of the skin densely populated with pilo-sebaceous units and C. acnes such as the central face, upper chest, and back (17–22).