Consistent with HFD or ER stress-induced SREBP1 signaling activation, HSP60 overexpression activated mTORC1-SREBP1 signaling and hepatic lipogenesis (Fig. 4C and D), whereas the knockdown of HSP60 suppressed ER stress-induced mTORC1-SREBP1 signaling and hepatic lipogenesis (Fig. 4E and F), suggesting that HSP60 might be involved in ER stress-induced mTORC1-SREBP1 signaling associated with lipogenesis and steatosis (Fig. 4G). Here, SREBF1 is linked to steatosis.