In this study, we have confirmed that ER stress is important in the regulation of hepatic lipogenesis, which was consistent with the previous reports about ER stress-induced hepatic steatosis and insulin resistance (Hu & Liu 2011, Yecies et al. 2011, Chen et al. 2017, Ghemrawi et al. 2018, Han & Wang 2018, Luo et al. 2018). The gene discussed is INS; the disease is fatty liver disease.