S100A8 and cancer: However, chronic inflammation, which is associated with cagA-positive H. pylori infection, has been reported to promote the oncogenesis of cancer-predisposed gastric epithelial cells.165 To experimentally investigate whether the inflammatory response can enhance the pro-oncogenic action of CagA in vivo, WT cagAE-Tg mice, which systemically expressed CagA, were treated with a colitis inducer, dextran sulfate sodium (DSS).