The reason why there no association of 1q419 (rs17465637, MIA3) and 10q11.21 (rs501120, CXCL12) with future events was observed may come from the difference in various ethnicities or various CHD definitions (myocardial infarction, coronary angioplasty or bypass graft). The gene discussed is CXCL12; the disease is myocardial infarction.