A prospective study of a multiethnic cohort, which is similar to ours investigating the same SNP markers, 9p21.3 (rs1333049; CDKN2B), 1q419 (rs17465637, MIA3) and 10q11.21 (rs501120, CXCL12), reported 9 loci, including the 9p21 region, and CXCL12 (rs501120), which were statistically associated with incident CHD events in the white population but not in the Asian/Pacific population, and only the 9p21 region showed significant between-study heterogeneity23. This evidence concerns the gene MIA3 and coronary artery disorder.