Furthermore, the association between a SNP in the 9p21 region and incident CHD was replicated in Asian/Pacific ethnicity later, but no significant association between 1q419 (rs17465637, MIA3) or 10q11.21 (rs501120, CXCL12) and CHD was observed in the Asian population in this replication study23. This evidence concerns the gene CXCL12 and coronary artery disorder.