To further investigate this, we incubated a panel of cell lines (two murine microglial cell lines, BV-2 and EOC-20; a human myeloma cell line, RPMI 8266; a human lung fibroblast cell line, WI-38) with YU102, ONX 0914 (LMP7-selective), or carfilzomib (an FDA-approved inhibitor targeting multiple proteasome subunits including X and LMP7, a positive control known to induce cell death) and performed cell viability assays. Here, PSMB8 is linked to plasma cell myeloma.