Likewise, we next identified differentially expressed genes (FDR = 0.01) in leukemic BM from both Pax5-het/Aid-het (Supplementary Fig. 8 and Supplementary Data 1) and Pax5-het/Aid-KO (Supplementary Fig. 9 and Supplementary Data 2) mice compared with BM precursor B cells from wild-type mice, showing that AID-deficient B-ALL exhibited a gene expression pattern that is similar to AID-het B-ALL (Supplementary Fig. 10). Here, PAX5 is linked to precursor B-cell acute lymphoblastic leukemia.