Notably, although the expression of LDHA is slightly higher than LDHB (LDHA/LDHB ranges from 1.2 to 1.4, except in U251 cells, in which LDHA is barely detected) in various cancer or transformed cells (Supplementary Fig. 2j), LDHB, not LDHA, directly interacts with Aurora-A in the cytoplasm of p53-deficient cells. This evidence concerns the gene LDHB and cancer.