We first scanned the relative expression level of ZNF667-AS1 and ZNF667 in various tumor types in Gene Expression Profiling Interactive Analysis (GEPIA) data set, and found significant downregulation of ZNF667-AS1 and ZNF667 in most of the tumor types, including bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), and esophageal carcinoma (ESCA) (Fig. 1b; Supplementary Fig. S2). The gene discussed is ZNF667; the disease is invasive breast carcinoma.