ZNF667 and esophageal cancer: Four esophageal cancer cells were treated with DNA methyltransferase inhibitor 5-Aza-dC or histone deacetylase inhibitor TSA, as shown in Fig. 2b, c, the expression levels of ZNF667-AS1 and ZNF667 were significantly increased in the 5-Aza-dC or TSA treated cells, especially in the 5-Aza-dC+TSA treated cells.