The 5-year survival rate of ESCC patients with low ZNF667-AS1 or ZNF667 expression level (the expression level of ZNF667-AS1 or ZNF667 in tumor tissues was lower than 50% of that in the corresponding normal tissues) was significantly lower than that with high ZNF667-AS1 or ZNF667 expression level (P < 0.05) (Fig. 1h). This evidence concerns the gene ZNF667 and esophageal squamous cell carcinoma.