4MOSC2 tumors also exhibited much higher density of lymphatic vessels staining positive for LYVE-1 than in 4MOSC1 (Fig. 2c), which is aligned with the strong correlation between intratumoral (IT) lymphangiogenesis and metastasis in human HNSCC (reviewed in ref. 29). Here, LYVE1 is linked to head and neck squamous cell carcinoma.