In addition, we found that SKA3 interacted with CDK2 by immunoprecipitation experiments, and overexpression of SKA3 inhibited the binding of CDK2 and p53, that is, SKA3 and CDK2, which were highly expressed in hepatoma cells, bound to each other and prevent the activation of p53 pathway, thereby promoting liver cancer growth and invasion. This evidence concerns the gene TP53 and liver cancer.