Within a retrospective evaluation of 88 patients with neuroendocrine lung tumors using immunhistochemistry, nestin was detected in 17% of specimens, being a negative prognostic factor and significantly higher expressed in LCNEC in comparison to carcinoids.[41] This suggests that the CSC amount increases from TC to AC and LCNEC to SCC, indicated by a higher expression of nestin, leading to a decrease in the survival rate of the patient. Here, NES is linked to large cell neuroendocrine carcinoma.