TNF and melanoma: Treatment of human LY CAR T cells with compound 8 significantly enhanced their cytotoxic potential, as assessed by the expression of IFNγ and TNF, in response to CAR crosslinking (with α‐LY) or engagement with LY‐expressing human ovarian (OVCAR‐3) carcinoma cells, but not melanoma cells (MDA‐MB‐435) that do not express LY (Fig 8A).