AGT and cardiac hypertrophy: The collective characterization of the hemodynamic, biochemical, and rat and human expressions of renin angiotensin system components in the blood and cardiac tissue of rats expressing the human AGT gene offers new insights into the biological importance of alternate Ang II generating pathways whereby shorter sequences of the AGT substrate lead to chronic hypertension and cardiac hypertrophy through non-canonical renin angiotensin biotransformation pathways.