A PGC1α-dependent pathway increases mitochondrial biogenesis, mitochondrial fission, mitophagy, proteolysis, and antioxidant response in endometrial cancer (Cormio et al., 2017), and haplogroup D shows significant correlation with the incidence of endometrial cancer in the Yunnan province in China (Xu et al., 2006). The gene discussed is PPARGC1A; the disease is endometrial cancer.