Suppression of KISS1 expression is closely related to DNA methylation in CRC tissues (Chen et al., 2014), while KISS1 overexpression has been reported to inhibit the invasion of CRC cells by blocking PI3K/AKT signaling (Chen et al., 2016; Chipman and Pasquinelli, 2019). The gene discussed is AKT1; the disease is colorectal carcinoma.