Ashraf et al. (2017) highlighted the deregulation of UHRF1 in various cancers, including CRC, and its prognostic value in cancers. This highlights UHRF1 dysregulation and the importance of identifying different strategies to target UHRF1 in cancers, as well as the prognostic value of UHRF1 (Ashraf et al., 2017). Therefore, UHRF1 may be an important biomarker in the diagnosis, treatment, and prognosis of CRC. Here, UHRF1 is linked to colorectal carcinoma.