UHRF1 and familial pancreatic carcinoma: In addition, UHRF1 can inhibit cell apoptosis through the ROS-related signaling pathway in gastric cancer (Zhang et al., 2018), and UHRF1 was found to enhance the invasive ability of tumor cells through the Keap1-Nrf2 pathway in pancreatic cancer (Abu-Alainin et al., 2016).