ESR1 and central nervous system cancer: As a result, we accessed some key methylation features (sites) related to the classification of gliomas annotated onto multiple genes, such as FLJ37543, LCE3D, FAM89A, ADCY5, ESR1, C2orf67, REST, EPHA7, etc. Furthermore, we obtained several biological functions related to the classification of glioma subtypes, which are also related to gene methylation and corresponding functions, such as cellular developmental process, neuron differentiation, cellular component morphogenesis, and G-protein-coupled receptor signaling pathway.