In this study, we focused on three subtypes of IDH-mutation gliomas by methylation data, including astrocytomas with IDH mutations (A-IDH), astrocytoma with IDH mutation and enriched HG (A-IDH-HG), and oligodendrogliomas with IDH mutations (O-IDH). This evidence concerns the gene IDH2 and astrocytoma (excluding glioblastoma).