As for its specific role for glioma subtyping, similar with gene ARHGEF3, such microRNA participates in TGF-beta signaling pathway (Yan et al., 2013) and has been validated to have different methylation status together with expression pattern in different IDH expression glioma subtypes (Kondo et al., 2014). The gene discussed is ARHGEF3; the disease is central nervous system cancer.