RUNX1 and acute myeloid leukemia: In an interesting retrospective analysis of children with CBF-AML, Manara et al. found several differences between t(8;21) and inv(16)/t(16;16) AML, with a higher occurrence of KIT mutation in RUNX1-RUNX1T1- compared to CBFB-MYH11-rearranged patients (33).