FLT3 and acute myeloid leukemia: In 2018, the FDA approved Gilteritinib as monotherapy to treat adult patients with relapsed/refractory AML and FLT3 mutations based on interim analysis of the ADMIRAL phase 3 trial (NCT02421939), which proved the superiority of Gilteritinib as compared to salvage chemotherapy in adults with relapsed and/or refractory FLT3 mutated AML.