TERT and urinary bladder cancer: Somatic hotspot mutations within the promoter region of TERT are one of the most frequently occurring mutations in different cancers including bladder cancer, of which the most common variants are C>T transition at either of two positions: chr5:12952228 and chr5:1295250, 146 and 124 base-pairs upstream, respectively, of start codon (10, 24, 25).