Both these pathways may induce the expression of the three main family of EMT regulators: (i) the SNAIL family of zinc-finger transcription factors comprising SNAIL and SLUG; (ii) the zinc finger E-box binding homeobox (ZEB) family of transcription factors including ZEB1 and ZEB2; (iii) the TWIST family of basic helix-loop-helix (bHLH) transcription factors encompassing TWIST1 and TWIST2. The roles of these transcription factors in EMT have been well-established in a variety of cancers including CRC, and most of them showed correlation with the prognosis (65, 66). This evidence concerns the gene ZEB1 and cancer.