ITB correlates with PTB and is independently associated with a shorter survival time. In MMR-proficient tumors: high-grade ITB is associated with right-sided location, advanced T and N stage, LVI, infiltrating tumor margin, and shorter survival time; MMR–deficient cancers: high ITB is linked to higher tumor G, vascular invasion, infiltrating tumor margin, and more unfavorable survival time. Here, MRC1 is linked to cancer.