Indeed, a proteomic study found that in colorectal cancer cells a KRAS mutation in codon 12 leads to the overexpression of doublecortin like kinase 1 (DCLK1) and tyrosine-protein kinase MET, while in codon 13 brings to the overexpression of tight junction protein ZO-2 (47). This evidence concerns the gene KRAS and colorectal cancer.