RARRES2 and papilloma: In contrast, when doxycycline was given to mice from 1 week before the initiation of the DMBA/TPA protocol up to the end of week 10, allowing expression of chemerin before the first papillomas became detectable, the number of papillomas developping in K5-chemerin mice was lower than that in wild-type mice, whether or not they had been treated with doxycycline during the first part of the procedure (Figure 7B).