In addition, when the doxycycline treatment was pursued up to the end of week 18, when a significant number of papillomas had appeared in the wild-type groups and the doxycycline-treated K5-chemerin group, reexpression of chemerin prevented further development of new papillomas, and delayed the growth of the ones already present, as well as their progression to carcinomas (Figure 7C). This evidence concerns the gene RARRES2 and carcinoma.