RARRES2 and papilloma: In addition, when the doxycycline treatment was pursued up to the end of week 18, when a significant number of papillomas had appeared in the wild-type groups and the doxycycline-treated K5-chemerin group, reexpression of chemerin prevented further development of new papillomas, and delayed the growth of the ones already present, as well as their progression to carcinomas (Figure 7C).