Mutations in isocitrate dehydrogenase (IDH) enzymes are found in 5–15% of patients with AML and inhibitors to both IDH1 (ivosidenib) and IDH2 (enasidenib) mutant enzymes have been approved by the FDA for treatment of relapsed and refractory AML patients. The gene discussed is IDH3A; the disease is acute myeloid leukemia.