Overexpression and upregulation of two enzymes of the oxidative phase, i.e., glucose-6-phosphate 1-dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (PGD), contributes to increased production of NADPH and ribose-5-phosphate in lung cancer (30). The gene discussed is G6PD; the disease is lung carcinoma.