At the same time, other studies have attempted to predict the status of IDH genotypes in patients with glioma through magnetic resonance (MR) or positron emission tomography (PET) imaging parameters, including the apparent diffusion coefficient and relative cerebral-blood-volume for MR and the tumor-to-brain ratio and time-to-peak for PET (11, 12). Here, IDH2 is linked to central nervous system cancer.