Other identified important variables were expression levels of profilin-1, β-tubulin chain, annexin-A5, and L7 ribosomal protein (Figure 2A) – their association with survival appeared stronger than association of any of the clinical/pathological variables (Breslow tumor thickness category, mitotic rate, T-category, histological tumor type or disease state). This evidence concerns the gene ANXA5 and neoplasm.