Despite these limitations, we believe that the present data clearly support the need for further evaluation (e.g., immunohistological verification; accurate quantification; evaluation of their relationship to histological tumor types and clinico-pathological staging) of association of hnRNP M and/or of HSP 90α early-stage CHNM expression levels and the risk of metastases occurrence. The gene discussed is HNRNPM; the disease is neoplasm.