Frequent symptoms of copper deficiency include hypocupremia, impaired iron mobilization, anemia, leucopenia, neutropenia, decreased super oxide dismutase (SOD) (particularly erythrocyte SOD (ESOD)), ceruloplasmin as well as cytochrome-c oxidase, but increased plasma cholesterol and LDL: HDL cholesterol and abnormal cardiac function [23,24]. Here, SOD1 is linked to anemia (phenotype).