RHD and B-cell chronic lymphocytic leukemia: Some studies showed arguments in favor of T cells participation in the generation of antibodies associated with AIHA and CLL: in patients with idiopathic AIHA - presence of Treg clones specific for Rh epitopes [22], Treg cells increase with disease progression in patients with CLL and AIHA compared to CLL patients without AIHA, an inverse relationship between the lymphocyte doubling time and the number of Treg [23], the administration of fludarabine, drug considered a risk factor for the development of autoimmune cytopenia in CLL, is followed by decreased Treg cell function [24].