Multicenter studies revealed that APL with presence of t (15;17)/PML-RARA, or those with t(8;21) / RUNX1-RUNX1T1/AML1(21q22)-ETO(8q22) with or without additional abnormalities (del (9)(q22)) or with inv (16)/t(16;16)/CBFB-MYH11 is accompanied by positive developments, a good response to chemotherapy, a high rate of remission and prolonged DFS [1,2]. The gene discussed is RUNX1; the disease is acute promyelocytic leukemia.