As shown in Figure 3A, the individuals with hrHPV infection and cGAS methylation levels above 31.87% might increase the 7.70-fold risk of CPL compared with the others, who had cGAS methylation levels lower than or equal to 31.87% and were hrHPV-negative (ORa = 7.70, 95% CI = 2.84-20.88, Pa < 0.001). This evidence concerns the gene CGAS and congenital pulmonary lymphangiectasia.