Viral infection of the host can trigger innate immune responses, and previous studies have revealed that cyclic GMP-AMP synthase (cGAS)/STING and RIG-I/MAVS pathways play important roles in host innate immunity against HPV-induced precursor lesions and invasive cancer of the uterine cervix (Karim et al., 2013; Lau et al., 2015; Xiao et al., 2016). Here, MAVS is linked to uterine cervix neoplasm.