The methylation levels in the promoter regions of cGAS, MAVS, and TRAF3 were significantly increased in the CPL group compared with the healthy control group, while there were no statistically significant differences between the control and CC groups, suggesting that aberrant DNA methylation in the gene promoter regions of cGAS, MAVS, and TRAF3 are the early events in the progression of cervical neoplasm. Here, CGAS is linked to uterine cervix neoplasm.