Whether spontaneous inflammation develops in the NKp46-Cre-Il10fl/fl mice was intriguing because both conventional Il10−/−mice and T cell-specific Il10-deficient mice on the C57BL/6 background develop rectal prolapse and diarrhea that are indicators of severe spontaneous intestinal inflammation at 6 months of age (47). The gene discussed is NCR1; the disease is inflammation.