CSF2 and diabetes mellitus: The supporting evidence includes: (1) treatment with human GM-CSF ameliorates Crohn's disease (68); (2) GM-CSF prevents diabetes development in NOD mice by promoting immature tolerogenic DCs and controlling the number of regulatory T cells (69); (3) GM-CSF deficiency in mouse results in the development of lupus-like disorder (70) while combined deficiency of GM-CSF and IL-3 results in the development of autoimmune diabetes (71).