By measuring the expression levels of different targets in bronchial explants from CF and non-CF patients, we showed no significant increase in miR-636 and RANK expression levels, a significant decrease in IL1R1 expression, significant increases in IKBKB, FAM13A, and IL-8 expression levels, and apparent decrease in IL-6 mRNA expression in bronchial explants of CF patients compared to those of healthy subjects. The gene discussed is IL1R1; the disease is cystic fibrosis.