In comparison to HC, CD49a+ NK cells from PBC patients represent an activated phenotype characterized by enrichment of the inflammatory response (normalized enrichment score [NES]: 2.3), signaling through IL-6/STAT3 (NES: 2.3), oxidative phosphorylation (NES: −2.4), TNFα signaling (NES: 2.0), and KRAS signaling (NES: 2.0) (Figure 2C). This evidence concerns the gene TNF and primary biliary cholangitis.