In PBC however there was a higher frequency of CXCR6 on CD56dim NK cells, the cytotoxic subpopulation (3.2 vs. 1.9%, p < 0.05), and of CD49a on both the CD56bright (4.4 vs. 2.2%, p < 0.05) and CD56dim (1.8 vs. 1.2%, p < 0.02) NK cells, as compared to HFe controls (Figure 1D). Here, CXCR6 is linked to primary biliary cholangitis.