As PBC is an inflammatory autoimmune disorder and our previous work had shown that intrahepatic NK cells expressing CD49a are associated with higher levels of IFNγ than CXCR6 (25), we further characterized the CD49a+ NK cell population by performing RNA sequencing on paired sorted peripheral blood CD49a+ and CD49a- NK cells from three patients with PBC, and peripheral blood derived NK cells from three HC. The gene discussed is CXCR6; the disease is primary biliary cholangitis.