Whilst CD49a+ NK cells from HFe and HC groups also secreted IFNγ in response to low dose IL-12, this was significantly less than from PBC patients [PBC 8.6% (range 0–43.0%) vs. HFe 2.6% (range 0–8.2%), p < 0.02 and HC 1.4% (range 0–5.1%), p < 0.005] (Figure 4C). The gene discussed is IFNG; the disease is primary biliary cholangitis.