However, stimulation with IL-12 0.005 ng/ml led to an increase in CD49a+CXCR6+ double-positive NK cells in individuals with PBC compared to those with HFe (0.24 vs. 0.17%, p < 0.05), and compared to culture of PBC NK cells in media alone (0.24 vs. 0.17%, p < 0.005) (Figure 3C). Here, ITGA1 is linked to primary biliary cholangitis.