Figure 2B shows a summary of all three comparisons. A total of 66 DEG were related with PBC independent of CD49a expression, constituting a common PBC signature. Upregulated genes included LTBP1, NECTIN2, TNFRSF10D, NKTR, TLR7, IFIT1, IFIT2, IFIT3, ERAP2, and MCOLN2. In addition, 305 DEGs were exclusively detected on HC vs. PBC CD49a+ NK cells, and 132 were detected when comparing CD49a+ vs. PBC CD49a- NK cells. Here, MCOLN2 is linked to primary biliary cholangitis.