CD4 and Hepatomegaly: Finally, interleukin (IL)-2 and interferon gamma (IFN-γ) production by CD4 T cells was higher in patients with hepatomegaly, and chemokine receptor CCR5 known to be expressed on Th1 cells was shown to be higher on CD4 T cells in patients with granulomas (61), implying Th1 bias in these patients.