MMP1 and coinfection: The sequencing data were verified by verifying 10 genes selected from the RNA-Seq expression profiles with the co-infection group via the qRT-PCR method, including upstream (IL-17C, NFκB,AP1, and C/EBPβ) and downstream genes (CXCL1, CXCL8, MMP1, MMP3, GM-CSF, and MUC5AC), as shown in Figure 5B.