In NB, they found 20 MES TF genes with strong MES-specific super-enhancers, for example, MEOX1, MEOX2, SIX1, SIX4, SOX9, SMAD3, and WWTR1 and 18 ADRN super-enhancer-associated TF genes, including ASCL1, EYA1, GATA3, HAND1, and SIX. These super-enhancer-associated TF genes are therefore candidate master gene regulators of the two cell types. Here, TF is linked to neuroblastoma.