In vitro studies have demonstrated that recombinant human resistin could induce insulin resistance through 5′AMP-activated protein kinase (AMPK)-dependent and AMPK-independent suppressor of cytokine signaling-3 (SOCS-3) signaling pathways in HepG2 cells (Luo et al., 2009), which is similar to the related rodent studies (Muse et al., 2004; Steppan et al., 2005). The gene discussed is SOCS3; the disease is Insulin resistance.