Additionally, TAMs-secreted CXCL1 could recruit MDSCs into the tumor microenvironment, which secreted chemokines including S100A8/9 that enhance cancer cell survival, chemoresistance, metastasis, and pre-metastatic niche formation (Acharyya et al., 2012; Miyake et al., 2016). This evidence concerns the gene S100A8 and neoplasm.