It is thus possible that P021, by virtue of its effect on retinal pathologies, normalized the tau/Aβ–induced neuroinflammation in aged 3xTg-AD mice and rats, which in turn contributed to the beneficial effect of P021 on the pathological changes of the RPE, neuronal loss in the retina, especially in the ONL and INL, and even the whole retina. The gene discussed is MAPT; the disease is Alzheimer disease.