Previous studies showed both tau and Aβ pathologies in the retina of 14 m Tg2576 mice (Liu et al., 2009; Hart et al., 2016) and APP immunoreactivity in the retina in a number of AD animal models, including Tg mouse models (hTgAPPtg/tg, APPSWE/PS1ΔE9, and APPSWE/PS1M146L/L286V) that exhibit several features of AD (Frederikse and Ren, 2002; Ning et al., 2008; Dutescu et al., 2009; Zhao et al., 2013; Du et al., 2015). Here, APP is linked to Alzheimer disease.