ABCA4 and age-related macular degeneration: Interestingly, we found a rosette-like formation in ~22- to 24-month-old rats, similar to the previous findings that were reported in the retina of a 92-year-old male with AMD (Rayborn et al., 1997) and in a 3-month-old Rdh8−/−/Abca4−/− mouse retina stained with H & E (Flynn et al., 2014).